Roscovitine-relatedpurinewithnoactivityonCDKs(usedascontrolforroscovitine).SelectivelyandpotentlyincreasesproductionofextracellularAbeta42anddecreasesproductionofextracellularAbeta38inculturedcells.ExtracellularAbeta40levelsremainstable.Intracellularlevelsoftheseamyloidsappeartoremainstable.Alzheimer"sDisease(AD)acceleratorthatinteractswithVDAC1,prohibitinandmitofilin,poss
IBLyinterferingwithsubcellularcompartmentalizationandlipidraftsproperties,shiftinggamma-secretaseactivitytowardAbeta42generation.InducesareversiblemitochondrialphenotypereminiscentoftheoneobservedinADbrains.TooltodetectinhibitorsofAftin-inducedactions(potentialanti-ADcompounds).Bindspyridoxalkinase.