Hello Bio/(R,S)-AMPA/HB0030/10mg,Hello Bio,,Hello Bio,hellobio,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Hello Bio/(R,S)-AMPA/HB0030/10mg

产品编号：HB0030-10mg

市场价：¥1384.50

场地：美国(厂家直采)

产品分类：生化试剂>缓冲液>酸碱缓冲液>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$71.00

品牌： Hello Bio

公司：Hello Bio

公司分类：

商品介绍

Productoverview

Name
(R,S)-AMPA
Shortdescription
PrototypicAMPAreceptoragoNIST
BIOLOGicaldescription
PrototypicAMPAreceptoragonist(EC₅₀=11μM).(S)-AMPAistheactiveenantiomerform.
Biologicalaction
Agonist
Purity
>98%
Ourproductsinaction
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Properties

Chemicalname
(RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid
MolecularWeight
186.17
Chemicalstructure
MolecularFormula
C₇H₁₀N₂O₄
CASNumber
74341-63-2
PubChemidentifier
1221
SMILES
CC1=C(C(=O)NO1)CC(C(=O)O)N
Source
Synthetic
InChi
InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
InChiKey
UUDAMDVQRQNNHZ-UHFFFAOYSA-N
MDLnumber
MFCD00213388
Appearance
Whitesolid

Applications

Applicationnotes
TheAMPAreceptoragonist(R,S)-AMPAistypicallyusedatconcentrationsof1-100µM.At10 µM,(R,S)-AMPAfromHelloBioinducesalargedepolarisingcurrent.ThisdepolarisingcurrentwasoccludedinthepresenceoftheAMPAreceptorantagonistNBQX(20µM).(SeeFig1above).

#Protocol1:(R,S)-AMPAprotocol
- WholecellvoltageclamprecordingsofCA1pyramidalneuronsfromtherathippocampalbrainslice.
- Neuronswereheldat-60mVandcontinuouslyperfusedwithaCSFinthepresenceoftheGABAreceptorantagonistgabazine(20µM).
- AMPAcurrentswereevokedviaapplying(R,S)-AMPAdirectlytotherecordingchamberduringcontinuousperfusion.
- Totesttheselectivityof(R,S)-AMPAtoAMPAreceptors,theexperimentwasrepeatedwithinthesameneuroninthepresenceoftheAMPAreceptorantagonistNBQX (20µM)
- Undertheseconditions(R,S)-AMPAfailedtoinduceadepolarisingcurrent.
StoringandUsingYourProduct
- Storageinstructions
  Roomtemperature
- Solubilityoverview
  Solubleinwater(10mM,gentlewarming)
- Important
  ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor(R,S)-AMPA
- TheAMPAreceptorbindingsite:focusonagonistsandcompetitiveantagonists.
  StensbølTBetal(2002)CurrPharmDes8(10):857-72.
  PubMedID:11945136
- Willardiinesdifferentiateagonistbindingsitesforkainate-versusAMPA-preferringglutamatereceptorsinDRGandhippocampalneurons.
  WongLAetal(1994)JNeurosci14(6):3881-97.
  PubMedID:7515954
- ActivationanddesensitizationofAMPA/kainatereceptorsbynovelderivativesofwillardiine.
  PatneauDKetal(1992)JNeurosci12(2):595-606.
  PubMedID:1371315
品牌介绍

Hello Bio由一群经验丰富的科学家和化学家组成，他们真心希望支持生命科学研究。Hello Bio的目标是生产和供应一系列高质量的生命科学工具，价格如此之低，使尽可能多的研究人员能够买得起。Hello Bio公司的目标是制造和供应一系列高质量的生命科学试剂，产品包括一系列激动剂，拮抗剂，抑制剂，激活剂，抗体和荧光工具，我们公司产品的价格是其他公司产品价格的一半，以便尽可能多的研究人员能够用得起。