Productoverview
- NameClozapineN-oxide(CNO)(watersoluble)
- ShortdescriptionWatersolubleprototypicalDREADDactivator.Clozapinemetabolite.
- BIOLOGicaldescription
ClozapineN-oxide(CNO)istheprototypicalchemicalactuatorforGq-DREADDs.Itisametaboliteoftheatypicalantipsychoticclozapine.
‘Excitatory’Gq-coupled)DREADDs:CNOactivatestheexcitatoryGq-coupledDREADDs:hM3Dq,hM1DqandhM5Dq.
ThehM3DqDREADDistypicallyusedforenhancingneuronalfiringandactivating(Gq-signalinginneuronalandnon-neuronalcells.
‘Inhibitory’(Gi-coupled)DREADDs:
CNOalsoactivatestheinhibitoryhM4DiandhM2DiGi-coupledDREADDs.
ThehM4DiDREADDisthemostcommonlyusedinhibitoryDREADDandisusedforneuronalsilencing.
Gsandβ-arrestincoupledDREADDs:
CNOalsoactivatestheGs-coupledDREADD(GsD)andtheβ-arrestinpreferringDREADD:rM3Darr(Rq(R165L).
CNOcanbeadmiNISTeredintraperitoneally(i.p.),subcutaneously,directlyinfusedintracranially,viadrinkingwaterorosmoticmini-pump.SeeourTechnicalreview(table3)forexampleadministrationmethodsanddoses.
RecentfindingssuggestthatsystemicallyadministeredCNOdoesnotreADIlycrosstheblood-brain-barrierinvivo,andconvertstoclozapinewhichactivatesDREADDs.Caremustbetakeninexperimentaldesignandpropercontrolsshouldbeincorporated. - AlternativenamesCNO
- BiologicalactionActivator
- Purity>98%
- Customercomments
YourtechnicalreviewonCNOstABIlity,solubilityanduseinthelabhasbeenreallyhelpfultomygroup.Verifiedcustomer
TheClozapineN-oxide(CNO)workedperfectly!ItdissolvedcompletelyinsalineatthedoseIamusingsonoproblemsthere!Verifiedcustomer,IstitutoItalianodiTecnologia
TheclozapineN-oxidedissolvesperfectlyinsaline,evenatahighdose!Verifiedcustomer,RadboudUniversity
- OurproductsinactionSubmitYourCitationNow
Images
Properties
- Chemicalname8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
- MolecularWeight342.82
- Chemicalstructure
![Clozapine N-oxide | [34233-69-7]](images/hellobio/201710/hb1807_2.png "Clozapine N-oxide | [34233-69-7]")
- MolecularFormulaC18H19ClN4O
- CASNumber34233-69-7
- PubChemidentifier2819
- SMILESC[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]
- SourceSynthetic
- InChiInChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h4-7,12,21H,8-11H2,1H3
- InChiKeyWYRDWWAASBTJLM-UHFFFAOYSA-N
- MDLnumberMFCD00210190
- AppearanceYellowsolid
Applications
- Applicationnotes
Non-CNODREADDactivators- Compound21(DREADDagonist21)hydrochloridehasminimaloff-targetactivityandisnotmetabolizedtoclozapine.ThefreebaseCompound21(DREADDagonist21)isalsoavailable.
- ThepotentandselectivehM3DqDREADDagonistPerlapinehydrochloride(watersoluble)andPerlapinearealsoavailable.
- SalvinorinB(SALB)SalvinorinB(SALB)whichpotentlyactivatestheinhibitoryKORDDREADDtoinduceneuronalinhibitionisalsoavailable.
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(100mM)
- Handling
Duringsolubilitytesting,precipitationwasfoundtooccurinsomeconcentrated(100mM)samples.
WethereforerecommendmakingupsolutionsandusingonsamedayifpossIBLe.Makingandhandlingofsolutionsshouldbeconductedinadustfreeenvironmentandensurethatproductandsolventsareatambienttemperaturebeforeuse.Pleasetakecaretoensurethatyourproductiscompletelydissolvedbeforeuse.Formoreinformation,readourreviewClozapineN-Oxide(watersoluble)-atechnicalreviewonstability,solubilityanduseinthelab.Itincludesdataonsolubility,storageandhandling,includingresultsfromourin-housetests,andguidelinesonuseinthelab,invivoandinvitro.
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforClozapineN-oxide(CNO)(watersoluble)
NoveldesignerreceptorstoprobeGPCRsignalingandphysiology.
Wessetal(2013)TrendsPharmacolSci.34(7):385-92PubMedID:23769625EvolvingthelocktofitthekeytocreateafamilyofGprotein-coupledreceptorspotentlyactivatedbyaninertligand.
Arbrusteretal(2007)ProcNatlAcadSciUSA.104(12):5163-8PubMedID:17360345TheroleofM1muscarinicreceptoragonismofN-desmethylclozapineintheuniqueclinicaleffectsofclozapine.
Weineretal(2004)Psychopharmacology(Berl).177(1-2):207-16PubMedID:15258717Achemical-geneticapproachtostudyGproteinregulationofbetacellfunctioninvivo.
Guettieretal(2009)ProcNatlAcadSciUSA106(45):19197-202PubMedID:https://www.ncbi.nlm.nih.gov/pub
Hello Bio由一群经验丰富的科学家和化学家组成，他们真心希望支持生命科学研究。Hello Bio的目标是生产和供应一系列高质量的生命科学工具，价格如此之低，使尽可能多的研究人员能够买得起。Hello Bio公司的目标是制造和供应一系列高质量的生命科学试剂，产品包括一系列激动剂，拮抗剂，抑制剂，激活剂，抗体和荧光工具，我们公司产品的价格是其他公司产品价格的一半，以便尽可能多的研究人员能够用得起。
本网站将在规定时间内给予删除等相关处理。
