Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 nM and 20 µM for PKC-α, PKC-β, PKC-γ, PKC-δ, PKC-ζ and PKC-µ respectively). Also suppresses TNF-α production (IC50 = 8.3 nM) and up-regulates Akt phosphorylation. Displays cardioprotective properties.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Go 6983
Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
Young LH et al (2005)
Cardiovasc Drug Rev 23(3) : 255-72.
PubMedID:
16252018
Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.
Foey AD et al (2004)
Immunology 112(1) : 44-53.
PubMedID:
15096183
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
Gschwendt M et al (1996)
FEBS Lett 392(2) : 77-80.
PubMedID:
8772178
PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.