Hello Bio/Go 6983/HB0303/10mg,Hello Bio,,Hello Bio,hellobio,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Hello Bio/Go 6983/HB0303/10mg

产品编号：HB0303-10mg

市场价：¥2164.50

场地：美国(厂家直采)

产品分类：生化试剂>缓冲液>酸碱缓冲液>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$111.00

品牌： Hello Bio

公司：Hello Bio

公司分类：

商品介绍

Product overview

Name
Go 6983
Short description
Broad spectrum PKC inhibitor
Biological description
Broad spectrum protein kinase C (PKC) inhibitor (IC₅₀ values are 7, 7, 6, 10, 60 nM and 20 µM for PKC-α, PKC-β, PKC-γ, PKC-δ, PKC-ζ and PKC-µ respectively). Also suppresses TNF-α production (IC₅₀ = 8.3 nM) and up-regulates Akt phosphorylation. Displays cardioprotective properties.
Biological action
Inhibitor
Purity
>98%
Our products in action
Submit Your Citation Now

Properties

Chemical name
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Molecular Weight
442.51
Chemical structure
Molecular Formula
C₂₆H₂₆N₄O₃
CAS Number
133053-19-7
PubChem identifier
3499
SMILES
CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
InChi
InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChiKey
LLJJDLHGZUOMQP-UHFFFAOYSA-N
MDL number
MFCD04040031

Storing and Using Your Product

Storage instructions
-20°C
Solubility overview
Soluble in DMSO (50mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Go 6983

Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury.
Young LH et al (2005) Cardiovasc Drug Rev 23(3) : 255-72.
PubMedID: 16252018
Conventional protein kinase C and atypical protein kinase Czeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10.
Foey AD et al (2004) Immunology 112(1) : 44-53.
PubMedID: 15096183
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes.
Gschwendt M et al (1996) FEBS Lett 392(2) : 77-80.
PubMedID: 8772178
PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.
Kim SY et al (2011) BMB Rep 44(2) : 140-5.
PubMedID: 21345315

品牌介绍

Hello Bio由一群经验丰富的科学家和化学家组成，他们真心希望支持生命科学研究。Hello Bio的目标是生产和供应一系列高质量的生命科学工具，价格如此之低，使尽可能多的研究人员能够买得起。Hello Bio公司的目标是制造和供应一系列高质量的生命科学试剂，产品包括一系列激动剂，拮抗剂，抑制剂，激活剂，抗体和荧光工具，我们公司产品的价格是其他公司产品价格的一半，以便尽可能多的研究人员能够用得起。

公司介绍

更多...

产品分类

更多...

Antagonists & inhibitors Antibiotics Agonists & activators Primary Dyes & stains

销售排行

更多...

Hello Bio/Pseurotin A/HB4038/5mg

$228.00

Hello Bio/(-)-Bicuculline methiodide/HB0893/10mM (add 1ml water)

$21.00

Hello Bio/Hoechst 33342/HB0787/100mg