Hello Bio/Picrotoxin/HB0506/1g,Hello Bio,,Hello Bio,hellobio,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Hello Bio/Picrotoxin/HB0506/1g

产品编号：HB0506-1g

市场价：¥468.00

场地：美国(厂家直采)

产品分类：生化试剂>缓冲液>酸碱缓冲液>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$24.00

品牌： Hello Bio

公司：Hello Bio

公司分类：

商品介绍

Productoverview

Name
Picrotoxin
Shortdescription
Non-competitiveGABA_AreceptorantagoNIST
BIOLOGicaldescription
Non-competitiveGABA_Areceptorantagonist.Alsoaglycinereceptorinhibitor(IC₅₀=2.7µM).ActsasaconvulsantandCNSstimulant.Activeinvivo.
Alternativenames
PTX
Biologicalaction
Antagonist
Purity
>98%
Customercomments
GettingonwellwithDHPG&picrotoxin–theydowhatthey’resupposedto!ProfessorBrunoFrenguelli,UniversityofWarwick,UK
Ourproductsinaction
3citationsSubmitYourCitationNow

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Properties

MolecularWeight
602.59
Chemicalstructure
MolecularFormula
C₃₀H₃₄O₁₃
CASNumber
124-87-8
PubChemidentifier
518601
SMILES
CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
InChi
InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3
InChiKey
VJKUPQSHOVKBCO-UHFFFAOYSA-N
MDLnumber
MFCD00074824

Applications

Applicationnotes
TheGABA_AreceptorantagonistPicrotoxiniscommonlyusedtoreducethelevelsinhibitionbyblockingtheactionsoftheneurotransmitterGABA.PicrotoxinfromHelloBioreducesbothspontaneousinhibitorypostsynapticcurrents(IPSC)andevokedIPSCs.Itwaseffectiveatconcentrationsof10μM,withcompletereceptorblockadeat100μM.Forassayprotocol,see#Protocol1inApplicationNotesbelow

#Protocol1:Evokedandspontaneousinhibitorypostsynapticcurrents(IPSCs)
- WholecellvoltageclamprecordingswereobtainedfromlayerVneuronsofthemouseprelimbiccortexbrainslice.
- AstimulatingelectrodewasplacedinlayersII/IIIandIPSCswereevokedbyasinglesquare(150μs)pulseevery10secatastimulusintensitythatgaveareliableIPSC.
- IPSCswereevokedatarangeofneuronholdingvoltagestomeasurethereversalpotentialofthecurrenttoensureitwasGABAergic.
- Neuronswereheldat0mVandIPSCscontinuouslystimulatedandrecordedinresponseto5minapplicationsofvaryingconcentrationsofGabazineuntilcompletereceptorinhibition.
- SpontaneousIPSCswererecordedbeforeandafteradditionofGabazinebyholdingtheneuronat0mVandrecordingfor10sec.
- AllrecordingsforIPSCsweremadeinthepresenceofAMPARantagonists.

StoringandUsingYourProduct

Storageinstructions
Roomtemperature
Solubilityoverview
SolubleinDMSO(100mM)andinethanol(50mM,gentlewarming)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforPicrotoxin

Picrotoxin-likechannelblockersofGABAAreceptors.
OlsenRW(2006)ProcNatlAcadSciUSA103(16):6081-2.
PubMedID:16606858
Mechanismsforpicrotoxinblockofalpha2homomericglycinereceptors.
WangDSetal(2006)JBiolChem281(7):3841-55.
PubMedID:16344549
Picrotoxinblockadeofinvertebrateglutamate-gatedchloridechannels:subunitdependenceandevidenceforbindingwithinthepore.
EtterAetal(1999)JNeuRochem72(1):318-26.
PubMedID:9886084

品牌介绍

Hello Bio由一群经验丰富的科学家和化学家组成，他们真心希望支持生命科学研究。Hello Bio的目标是生产和供应一系列高质量的生命科学工具，价格如此之低，使尽可能多的研究人员能够买得起。Hello Bio公司的目标是制造和供应一系列高质量的生命科学试剂，产品包括一系列激动剂，拮抗剂，抑制剂，激活剂，抗体和荧光工具，我们公司产品的价格是其他公司产品价格的一半，以便尽可能多的研究人员能够用得起。

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