Product overview

• Name
  U0126
• Short description
  Potent, selective MEK-1/MEK-2 inhibitor
• Biological description
  Potent, selective and non-competitive MAP kinase kinase (MAP2K) inhbitor. Inhibits both MEK-1 and MEK-2 (IC₅₀ values are 72 and 58 nM respectively) while showing little or no effect on many other kinases. Inhibits AP-1 transactivation and shows many other actions. Active in vivo.
• Biological action
  Inhibitor
• Purity
  >99%
• Our products in action
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Properties

• Chemical name
  1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
• Molecular Weight
  380.48
• Chemical structure
  
• Molecular Formula
  C₁₈H₁₆N₆S₂
• CAS Number
  109511-58-2
• PubChem identifier
  3006531
• SMILES
  C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)N)/C#N)C#N)/N
• InChi
  InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
• InChiKey
  DVEXZJFMOKTQEZ-JYFOCSDGSA-N
• MDL number
  MFCD25977152

Storing and Using Your Product

• Storage instructions
  +4°C (desiccate)
• Solubility overview
  Soluble in DMSO (100mM)
• Important
  This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.