Non-selective JAK3 inhibitor (IC50 = 1.8 µM), also acts as a potent EGFR kinase inhibitor (IC50 = 4 nM). Inhibits expression of iNOS and production of NO. Also induces neural progenitor cell differentiation. Shows apoptotic and anti-tumor actions.
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for WHI-P 154
The specificity of JAK3 kinase inhibitors.
Changelian PS et al (2008)
Blood 111(4) : 2155-7.
PubMedID:
18094329
Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.
Sareila O et al (2008)
Int Immunopharmacol 8(1) : 100-8.
PubMedID:
18068105
4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells.
Narla RK et al (1998)
Clin Cancer Res 4(6) : 1405-14.