Product overview

  • NameE-4031 dihydrochloride
  • Short descriptionPotent, selective Kv11.1 channel blocker
  • Biological descriptionPotent and selective Kv11.1 (hERG) channel blocker (IC50 = 7.7 nM in HEK 293 cells). Delayed rectifier K2+ current inhibitor. Shows antiarrhythmic actions.
  • Biological actionBlocker
  • Purity>98%
  • Our products in actionSubmit Your Citation Now


  • Chemical nameN-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
  • Molecular Weight474.44
  • Chemical structure\"E-4031
  • Molecular FormulaC21H27N3O3S.2HCl
  • CAS Number113559-13-0

Storing and Using Your Product

  • Storage instructionsroom temperature (desiccate)
  • Solubility overviewsoluble in water (100mM) or DMSO (50mM)
  • ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for E-4031 dihydrochloride

  • Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.

    Kim I et al (2005)J Appl Physiol (1985) 98(4) : 1469-77. PubMedID: 15591286
  • Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.

    Wettwer E et al (1991)J Cardiovasc Pharmacol 17(3) : 480-7. PubMedID: 1711611
  • Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.

    Zhou Z et al (1998)Biophys J 74(1) : 230-41. PubMedID: 9449325