Product overview

• NameCMIQ
• Short descriptionPotent, selective PKA inhibitor
• Biological descriptionPotent and selective protein kinase A (PKA) inhibitor (IC₅₀ = 30 nM ). Membrane permeable. Blocks ATP-binding site of PKA. Restores morphine-related behaviours in morphine tolerance.
• Biological actionInhibitor
• Purity>95%
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Properties

• Chemical namePKA Inhibitor XI
• Molecular Weight168.2
• Chemical structure
• Molecular FormulaC₁₁H₈N₂
• CAS Number161468-32-2

Storing and Using Your Product

• Storage instructions+4°C
• Solubility overviewsoluble in DMSO (50mg/ml)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CMIQ

• PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.

  Smith FL et al (2006)Pharmacol Res 54(6) : 474-80. PubMedID: 17056270

• Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives.

  Lu ZX et al (1996)Biol Chem Hoppe Seyler 377(6) : 373-84. PubMedID: 8839983

• Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

  Hucho TB et al (2005)J Neurosci 25(26) : 6119-26. PubMedID: 15987941