Product overview

  • Name(R,S)-3,5-DHPG
  • Short descriptionSelective group I (mGluR1 / mGluR5) agonist
  • Biological descriptionSelective group I mGluR (mGluR1 / mGluR5) agonist. Stimulates PLC and inhibits PLD response. Induces LTD in the hippocampus.
  • Alternative names(RS)-3,5-Dihydroxyphenylglycine
  • Biological actionAgonist
  • Purity>99%
  • Customer comments

    Getting on well with DHPG & picrotoxin – they do what they’re supposed to! Professor Bruno Frenguelli, University of Warwick, UK

  • Our products in action1 citationSubmit Your Citation Now


  • \"(R,S)-3,5-DHPG:


  • Chemical name(RS)-3,5-Dihydroxyphenylglycine
  • Molecular Weight183.16
  • Chemical structure\"(R,S)-3,5-DHPG
  • Molecular FormulaC8H9NO4
  • CAS Number19641-83-9
  • PubChem identifier108001
  • SourceSynthetic
  • InChiInChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
  • AppearanceWhite solid

Storing and Using Your Product

  • Storage instructions-20°C (desiccate)
  • Solubility overviewSoluble in water (10mM)
  • ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-3,5-DHPG

  • Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.

    Pellegrini-Giampietro DE et al (1996)Br J Pharmacol 118(4) : 1035-43. PubMedID: 8799579
  • The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

    Palmer MJ et al (1997)Neuropharmacology 36(11-12) : 1517-32. PubMedID: 9517422
  • Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.

    Kumar A et al (2014)Hippocampus 24(4) : 466-75. PubMedID: 24390964