Product overview

• NameE-4031 dihydrochloride
• Short descriptionPotent, selective K_v11.1 channel blocker
• Biological descriptionPotent and selective K_v11.1 (hERG) channel blocker (IC₅₀ = 7.7 nM in HEK 293 cells). Delayed rectifier K²⁺ current inhibitor. Shows antiarrhythmic actions.
• Biological actionBlocker
• Purity>98%
• Our products in actionSubmit Your Citation Now

Properties

• Chemical nameN-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
• Molecular Weight474.44
• Chemical structure
• Molecular FormulaC₂₁H₂₇N₃O₃S.2HCl
• CAS Number113559-13-0

Storing and Using Your Product

• Storage instructionsroom temperature (desiccate)
• Solubility overviewsoluble in water (100mM) or DMSO (50mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for E-4031 dihydrochloride

• Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.

  Kim I et al (2005)J Appl Physiol (1985) 98(4) : 1469-77. PubMedID: 15591286

• Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.

  Wettwer E et al (1991)J Cardiovasc Pharmacol 17(3) : 480-7. PubMedID: 1711611

• Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.

  Zhou Z et al (1998)Biophys J 74(1) : 230-41. PubMedID: 9449325