Product overview

• Name(R,S)-3,5-DHPG
• Short descriptionSelective group I (mGluR₁ / mGluR₅) agonist
• Biological descriptionSelective group I mGluR (mGluR₁ / mGluR₅) agonist. Stimulates PLC and inhibits PLD response. Induces LTD in the hippocampus.
• Alternative names(RS)-3,5-Dihydroxyphenylglycine
• Biological actionAgonist
• Purity>99%
• Customer comments

  Getting on well with DHPG & picrotoxin – they do what they’re supposed to! Professor Bruno Frenguelli, University of Warwick, UK

• Our products in action1 citationSubmit Your Citation Now

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Properties

• Chemical name(RS)-3,5-Dihydroxyphenylglycine
• Molecular Weight183.16
• Chemical structure
• Molecular FormulaC₈H₉NO₄
• CAS Number19641-83-9
• PubChem identifier108001
• SMILESC1=C(C=C(C=C1O)O)C(C(=O)O)N
• SourceSynthetic
• InChiInChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
• InChiKeyHOOWCUZPEFNHDT-UHFFFAOYSA-N
• AppearanceWhite solid

Storing and Using Your Product

• Storage instructions-20°C (desiccate)
• Solubility overviewSoluble in water (10mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (R,S)-3,5-DHPG

• Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.

  Pellegrini-Giampietro DE et al (1996)Br J Pharmacol 118(4) : 1035-43. PubMedID: 8799579

• The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

  Palmer MJ et al (1997)Neuropharmacology 36(11-12) : 1517-32. PubMedID: 9517422

• Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.

  Kumar A et al (2014)Hippocampus 24(4) : 466-75. PubMedID: 24390964